| Post: | Spouse of the deputy prime minister of Malaysia |
| Style: | Yang Amat Berbahagia |
| Incumbent: | Hamidah Khamis Ruziah Mohd Tahir |
| Incumbentsince: | 3 December 2022 |
| Residence: | Sri Satria, Putrajaya |
| Formation: | 31 August 1957 |
| First: | Rahah Noah |
The spouse of the deputy prime minister of Malaysia refers to the wife or husband of the Deputy Prime Minister of Malaysia. To date, twelve women and one man have held the title of the spouse of the deputy prime minister of Malaysia. The spouse of the present Deputy Prime Minister of Malaysia is Datin Sri Muhaini Zainal Abidin, with her husband, Ismail Sabri Yaakob was elected as Deputy Prime Minister of Malaysia on 7 July 2021.
| Portrait | Spouse (Birth-Death) | Term start | Term end | Deputy Prime Minister (Party) | |
|---|---|---|---|---|---|
| 1 | Tun Rahah Mohamed Noah (1933–2020) | 31 August 1957 | 22 September 1970 | Abdul Razak Hussein (Alliance-UMNO) | |
| 2 | Toh Puan Norashikin Mohd Seth (1932–2010) | 22 September 1970 | 2 August 1973 | Ismail Abdul Rahman (Alliance-UMNO) | |
| 3 | Tun Suhailah Mohamed Noah (1930–2014) | 13 August 1973 | 15 January 1976 | Hussein Onn (Alliance-UMNO) (BN-UMNO) | |
| 4 | Tun Dr. Siti Hasmah Mohamad Ali (b. 1927) | 5 March 1976 | 16 July 1981 | Mahathir Mohamad (BN-UMNO) | |
| 5 | Toh Puan Ines Maria Reyna (b. unknown) | 18 July 1981 | 16 March 1986 | Musa Hitam (BN-UMNO) | |
| 6 | Toh Puan Asmah Alang (1927–2004) | 10 May 1986 | 15 October 1993 | Ghafar Baba (BN-UMNO) | |
| 7 | Toh Puan Dayang Heryati Abdul Rahim (b. 1961) | 1992 | 15 October 1993 | ||
| 8 | Datin Seri Dr. Wan Azizah Wan Ismail (b. 1952) | 1 December 1993 | 2 September 1998 | Anwar Ibrahim (BN-UMNO) | |
| 9 | Tun Endon Mahmood Ambak (1940–2005) | 8 January 1999 | 31 October 2003 | Abdullah Ahmad Badawi (BN-UMNO) | |
| 10 | Datin Sri Rosmah Mansor (b. 1951) | 7 January 2004 | 3 April 2009 | Najib Razak (BN-UMNO) | |
| 11 | Puan Sri Noorainee Abdul Rahman (b. 1949) | 10 April 2009 | 29 July 2015 | Muhyiddin Yassin (BN-UMNO) | |
| 12 | Datin Seri Hamidah Khamis (b. 1955) | 29 July 2015 | 9 May 2018 | Ahmad Zahid Hamidi (BN-UMNO) | |
| 13 | Dato' Seri Anwar Ibrahim (b. 1947) MP for Port Dickson | 21 May 2018 | 24 February 2020 | Wan Azizah Wan Ismail (PH-PKR) | |
| 14 | Datin Sri Muhaini Zainal Abidin (b. 1962) | 7 July 2021 | 16 August 2021 | Ismail Sabri Yaakob (BN-UMNO) | |
| 15 | Datin Seri Hamidah Khamis (b. 1955) | 3 December 2022 | Incumbent | Ahmad Zahid Hamidi (BN-UMNO) | |
| Datin Seri Ruziah Mohd Tahir (b. unknown) | 3 December 2022 | Incumbent | Fadillah Yusof (GPS-PBB) | ||