Spondin 1 Explained

Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene.^[1] It is secreted by cells of the floor plate and may be involved in axon guidance^[2] The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.

Further reading

• Nakajima D, Okazaki N, Yamakawa H . Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones . DNA Res. . 9 . 3 . 99–106 . 2003 . 12168954 . 10.1093/dnares/9.3.99 . free .
• Klar A, Baldassare M, Jessell TM . F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension . Cell . 69 . 1 . 95–110 . 1992 . 1555244 . 10.1016/0092-8674(92)90121-R . 14880785 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Miyamoto K, Morishita Y, Yamazaki M . Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary . Arch. Biochem. Biophys. . 390 . 1 . 93–100 . 2001 . 11368520 . 10.1006/abbi.2001.2367 .
• Gonzalez de Peredo A, Klein D, Macek B . C-mannosylation and o-fucosylation of thrombospondin type 1 repeats . Mol. Cell. Proteomics . 1 . 1 . 11–8 . 2002 . 12096136 . 10.1074/mcp.M100011-MCP200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Ho A, Südhof TC . Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage . Proc. Natl. Acad. Sci. U.S.A. . 101 . 8 . 2548–53 . 2004 . 14983046 . 10.1073/pnas.0308655100 . 356987 . 2004PNAS..101.2548H . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Pyle-Chenault RA, Stolk JA, Molesh DA . VSGP/F-spondin: a new ovarian cancer marker . Tumour Biol. . 26 . 5 . 245–57 . 2005 . 16103746 . 10.1159/000087379 . 13409234 .
• Otsuki T, Ota T, Nishikawa T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Kitagawa M, Kudo Y, Iizuka S . Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells . Biochem. Biophys. Res. Commun. . 349 . 3 . 1050–6 . 2006 . 16965763 . 10.1016/j.bbrc.2006.08.142 .

Notes and References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 5 . 5 . 277–86 . Apr 1999. 9872452 . 10.1093/dnares/5.5.277 . free .
2. Web site: Entrez Gene: SPON1 spondin 1, extracellular matrix protein.