Spleen exonuclease explained

Spleen exonuclease
Ec Number:	3.1.16.1
Cas Number:	9068-54-6

Spleen exonuclease (3'-exonuclease, spleen phosphodiesterase, 3'-nucleotide phosphodiesterase, phosphodiesterase II) is an enzyme.^[1] This enzyme catalyses the following chemical reaction

Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates (exonuclease type b)

This enzyme has a preference for single-stranded substrate.

PLD3 and/or PLD4 might be the genes encoding spleen exonuclease, as they have similar substrate specificity and tissue distribution.^[2]

Notes and References

1. Book: Spleen acid nuclease . The Enzymes . Bernardi A, Bernardi G . 1971 . 4 . 329–336 . Boyer PD . 3rd . Academic Press . New York .
2. Gavin AL, Huang D, Huber C, Mårtensson A, Tardif V, Skog PD, Blane TR, Thinnes TC, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, Schulz SR, Zarpellon A, Cravatt B, Pang ES, Teijaro J, de la Torre JC, O'Keeffe M, Hochrein H, Damme M, Teyton L, Lawson BR, Nemazee D . 6 . PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing . Nature Immunology . 19 . 9 . 942–953 . September 2018 . 30111894 . 6105523 . 10.1038/s41590-018-0179-y .