Spiramide Explained

Spiramide (developmental code name AMI-193) is an experimental antipsychotic that acts as a selective 5-HT2A, 5-HT1A, and D2 receptor antagonist. It has negligible affinity for the 5-HT2C receptor.[1] [2] [3]

Notes and References

  1. Czoty PW, Howell LL . Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey . Pharmacology Biochemistry and Behavior . 67 . 2 . 257–64 . October 2000 . 11124389 . 10.1016/S0091-3057(00)00321-X. 36132685 .
  2. Luparini MR, Garrone B, Pazzagli M, Pinza M, Pepeu G . A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone . Progress in Neuro-psychopharmacology & Biological Psychiatry . 28 . 7 . 1117–27 . November 2004 . 15610924 . 10.1016/j.pnpbp.2004.05.046 . 24076522 .
  3. Hamada K, Yoshida M, Isayama H, Yagi Y, Kanazashi S, Kashihara Y, Takeuchi K, Yamaguchi I . Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice . Journal of Pharmacological Sciences . 105 . 3 . 240–50 . November 2007 . 17965538 . 10.1254/jphs.FP0071049. free .

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