| Spilios Zakharopoulos | |
| Nationality: | Greek |
| Sport: | Middle-distance running |
| Event: | 1500 metres |
| Birth Date: | 2 February 1950 |
Spilios Zakharopoulos (born 2 February 1950) is a Greek middle-distance runner. He competed in the 1500 metres at the 1972 Summer Olympics and the 1976 Summer Olympics.[1]