Spi-1 (PU.1) 5′ UTR regulatory element explained

Spi-1 (PU.1) 5′ UTR regulatory element
Symbol:	Spi-1
Rfam:	RF00232
Rna Type:	Cis-reg
Tax Domain:	Eukaryota

The Spi-1 (PU.1) 5′ UTR regulatory element is an RNA element found in the 5′ UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold.^[1] Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5′ UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.

See also

• InvR

Notes and References

1. Hensold JO, Stratton CA, Barth D . The conserved 5′-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivo . Nucleic Acids Research . 25 . 14 . 2869–2876 . July 1997 . 9207037 . 146829 . 10.1093/nar/25.14.2869 .