Sphingomyelin deacylase explained
| Sphingomyelin deacylase |
| Ec Number: | 3.5.1.109 |
Sphingomyelin deacylase (SM deacylase, GcSM deacylase, glucosylceramide sphingomyelin deacylase, sphingomyelin glucosylceramide deacylase, SM glucosylceramide GCer deacylase, SM-GCer deacylase, SMGCer deacylase) is an enzyme with systematic name N-acyl-sphingosylphosphorylcholine amidohydrolase.[1] [2] [3] This enzyme catalyses the following chemical reaction
(1) an N-acyl-sphingosylphosphorylcholine + H2O
a
fatty acid + sphingosylphosphorylcholine;
(2) a D-glucosyl-N-acylsphingosine + H2O
a fatty acid + D-glucosyl-sphingosine
The enzyme is involved in the sphingolipid metabolism in the epidermis.
Notes and References
- Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G . High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis . The Journal of Investigative Dermatology . 115 . 3 . 406–13 . September 2000 . 10951276 . 10.1046/j.1523-1747.2000.00072.x . free .
- Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G . The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide . The Biochemical Journal . 350 Pt 3 . 747–56 . September 2000 . 10970788 . 1221306 . 10.1042/0264-6021:3500747 .
- Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G . Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis . Laboratory Investigation; A Journal of Technical Methods and Pathology . 83 . 3 . 397–408 . March 2003 . 12649340 . 10.1097/01.lab.0000059931.66821.92 . free .
