Sperm-associated antigen 5 explained
Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene.[1] [2]
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.
Further reading
- Howard L, Nelson KK, Maciewicz RA, Blobel CP . Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1 . J. Biol. Chem. . 274 . 44 . 31693–9 . 1999 . 10531379 . 10.1074/jbc.274.44.31693 . free .
- Shao X, Xue J, van der Hoorn FA . Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1 . Mol. Reprod. Dev. . 59 . 4 . 410–6 . 2001 . 11468777 . 10.1002/mrd.1047 . 13590694 . free .
- Mack GJ, Compton DA . Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein . Proc. Natl. Acad. Sci. U.S.A. . 98 . 25 . 14434–9 . 2002 . 11724960 . 10.1073/pnas.261371298 . 64699 . free .
- Gruber J . The mitotic-spindle-associated protein astrin is essential for progression through mitosis . J. Cell Sci. . 115 . Pt 21 . 4053–9 . 2003 . 12356910 . 10.1242/jcs.00088 . vanc. Harborth J . Schnabel J . 3 . Weber . K . Hatzfeld . M . free. 11858/00-001M-0000-0012-F29B-B. free.
- Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
- Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
- Le XF . Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling . J. Biol. Chem. . 280 . 3 . 2092–104 . 2005 . 15504738 . 10.1074/jbc.M403080200 . vanc. Lammayot A . Gold D . 3 . Lu . Y . Mao . W . Chang . T . Patel . A . Mills . GB . Bast Jr . RC . free .
- Yang YC . Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells . Biochem. Biophys. Res. Commun. . 343 . 2 . 428–34 . 2006 . 16546135 . 10.1016/j.bbrc.2006.02.166 . vanc. Hsu YT . Wu CC . 3 . Chen . Hsiang-Ting . Chang . Mau-Sun .
- Nousiainen M . Phosphoproteome analysis of the human mitotic spindle . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . vanc. Silljé HH . Sauer G . 3 . Nigg . EA . Körner . R . 2006PNAS..103.5391N . free .
- Cheng TS . hNinein is required for targeting spindle-associated protein Astrin to the centrosome during the S and G2 phases . Exp. Cell Res. . 313 . 8 . 1710–21 . 2007 . 17383637 . 10.1016/j.yexcr.2007.02.023 . vanc. Hsiao YL . Lin CC . 3 . Hsu . Ching-Mei . Chang . Mau-Sun . Lee . Chu-I . Yu . Ricky Chang-Tze . Huang . Chi-Ying F. . Howng . Shen-Long .
Notes and References
- Chang MS, Huang CJ, Chen ML, Chen ST, Fan CC, Chu JM, Lin WC, Yang YC . Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins . Biochem Biophys Res Commun . 287 . 1 . 116–21 . Sep 2001 . 11549262 . 10.1006/bbrc.2001.5554 .
- Web site: Entrez Gene: SPAG5 sperm associated antigen 5.