Spectrin repeat containing nuclear envelope family member 3 explained

Spectrin repeat containing nuclear envelope family member 3, or Nesprin-3, is a Nesprin-family protein that in humans is encoded by the SYNE3 gene.^[1] Nesprin-3 localizes to the outer nuclear membrane, where it is retained by SUN domain-containing proteins. The n-terminus of Nesprin-3 faces the cytoplasm and associates with the cytolinker protein Plectin.^[2]

Further reading

• Nery FC, Zeng J, Niland BP, Hewett J, Farley J, Irimia D, Li Y, Wiche G, Sonnenberg A, Breakefield XO . 6 . TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton . Journal of Cell Science . 121 . Pt 20 . 3476–3486 . October 2008 . 18827015 . 3539201 . 10.1242/jcs.029454 .
• Morgan JT, Pfeiffer ER, Thirkill TL, Kumar P, Peng G, Fridolfsson HN, Douglas GC, Starr DA, Barakat AI . 6 . Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization . Molecular Biology of the Cell . 22 . 22 . 4324–4334 . November 2011 . 21937718 . 3216658 . 10.1091/mbc.E11-04-0287 .
• Liao M, Li B, Zhang S, Liu Q, Liao W, Xie W, Zhang Y . Relationship between LINC00341 expression and cancer prognosis . Oncotarget . 8 . 9 . 15283–15293 . February 2017 . 28146429 . 5362486 . 10.18632/oncotarget.14843 .

Notes and References

1. Web site: Entrez Gene: Spectrin repeat containing nuclear envelope family member 3. 2018-05-27.
2. Wilhelmsen K, Litjens SH, Kuikman I, Tshimbalanga N, Janssen H, van den Bout I, Raymond K, Sonnenberg A . 6 . Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin . The Journal of Cell Biology . 171 . 5 . 799–810 . December 2005 . 16330710 . 10.1083/jcb.200506083 . 2171291 .