Spatial Cultural-Historical Units of Great Importance (Serbian: Просторне културно-историjске целине од великог значаја/Serbian: Prostorne kulturno-istorijske celine od velikog značaja) are the monuments in Serbia that have the second level of the State protection.
Those are part of the Cultural Property of Great Importance protection list.
| style=background:#FFDEAD; | Picture | style=background:#FFDEAD; | Name | style=background:#FFDEAD; | Municipality/City | style=background:#FFDEAD; | Place, Address | style=background:#FFDEAD; | Year of inclusion | style=background:#FFDEAD; | Info |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Petrovaradin Fortress | Novi Sad | Petrovaradin | 1991 | ||||||||
| Subotica City Center | Subotica | Subotica | 1991 | ||||||||
| Cemeteries Out of Use | Novi Sad | Novi Sad | 1991 | ||||||||
| Greek Lane | Kruševac | Kruševac | 1979 | ||||||||
| Karačoni Castle | Novi Bečej | Novo Miloševo Maršala Tita No.84 | 1991 | ||||||||
| Ethno Park in Kupinovo | Pećinci | Kupinovo | 1991 | ||||||||
| Barley Market, Sremska Mitrovica | Sremska Mitrovica | Sremska Mitrovica | 1979 | ||||||||
| The Historic Core of Sombor - "Venac" | Sombor | Sombor | 1991 | ||||||||
| Lodine Spa | Novi Sad | Novi Sad | 1979 | ||||||||
| Godovik Complex | Požega | Godovik | 1983 | ||||||||
| Kosančićev Venac | Beograd | Stari Grad | 1979 | ||||||||
| Lukarevina Field | Aleksandrovac | Drenča | 1983 | ||||||||
| Rural Area with Watermills on Bistrica and Valjavica on the Bistrica river spring. | Petrovac | Bistrica No. | 1979 | ||||||||
| Novi Sad Synagogue | Novi Sad | Stari Grad Jevrejska ulica | 1991 | ||||||||
| Memorial Graveyard | Novi Sad | Novi Sad | 1991 | ||||||||
| Old Town | Belgrade | Grocka | 1979 | ||||||||
| Old Town | Ivanjica | Ivanjica | 1987 | ||||||||
| Old City Core | Belgrade | Zemun | 1979 | ||||||||
| Old City Core | Kragujevac | Kragujevac | 1979 | ||||||||
| Old City Core | Negotin | Negotin | 1983 | ||||||||
| Old City Core | Pančevo | Pančevo | 1991 | ||||||||
| Old Town Core | Pančevo | Banatsko Novo Selo | 1991 | ||||||||
| Old Town Core | Bečej | Bečej | 1991 | ||||||||
| Old Town Core | Zrenjanin | Zrenjanin | 1991 | ||||||||
| Old Town Core | Irig | Irig | 1991 | ||||||||
| National Heroes Square | Sremska Mitrovica | Sremska Mitrovica | 1991 | ||||||||
| Čajkino Hill | Vrnjačka Banja | Vrnjačka Banja | 1987 |