| Southern Railway Depot | |
| Location: | Jct. of Ninth St. and CBD Loop, North Wilkesboro, North Carolina |
| Coordinates: | 36.1586°N -81.1458°W |
| Architecture: | Bungalow/craftsman |
| Added: | September 10, 2004 |
| Area: | less than one acre |
| Refnum: | 04000965 |
Southern Railway Depot, also known as the North Wilkesboro Depot, is a historic train station located near North Wilkesboro, Wilkes County, North Carolina. It was built in 1914 by the Southern Railway, and is a long, one-story brick building with American Craftsman style design elements. It measures 36 feet wide and 240 feet long and has a low hipped roof with overhanging eaves. Passenger service ceased in 1955.[1]
It was listed on the National Register of Historic Places in 2004.