| Southern Lee High School | |
| Type: | Public |
| Ceeb: | 343524 |
| Principal: | Molly Poston |
| Faculty: | 175 |
| Teaching Staff: | 75.05 (FTE) |
| Ratio: | 16.44 |
| Enrollment: | 1,234 (2022–23)[1] |
| Grades: | 9–12 |
| Streetaddress: | 2301 Tramway Road |
| City: | Sanford, North Carolina |
| Zipcode: | 27332 |
| Country: | United States |
| District: | Lee County Schools |
| Campus Type: | Urban |
| Colors: | Navy and orange |
| Mascot: | Cavalier |
| Free Label: | Emblem |
| Pushpin Map: | North Carolina#USA |
Southern Lee High School is one of two high schools in Sanford, North Carolina, and serves grades 9–12. The school mascot is the cavalier and the school's colors are navy and orange.