| South Side High School | |
| Streetaddress: | 4949 State Route 151 |
| City: | Hookstown |
| State: | Pennsylvania |
| Zipcode: | 15050 |
| Country: | USA |
| Coordinates: | 40.5682°N -80.4369°W |
| District: | South Side Area School District |
| Principal: | Anthony C. Paull |
| Ratio: | 13.01 |
| Type: | Public, Coeducational high school |
| Grades: | 9-12 |
| Conference: | Western Pennsylvania Interscholastic Athletic League |
| Team Name: | Rams |
| Enrollment: | 328 (2019-20)[1] |
South Side High School is a public high school in Greene Township, Pennsylvania, United States. It is the only high school in the South Side Area School District. Athletic teams compete as the South Side Rams in the Western Pennsylvania Interscholastic Athletic League.