| State: | SD |
| Type: | SD |
| Route: | 46 |
| Section: | 166 |
| Length Mi: | 105.535 |
| Length Ref: | [1] |
| Map Notes: | Route of SD 46 (in red) |
| Established: | 1936 |
| Direction A: | West |
| Terminus A: | in Pickstown |
| Junction: |
|
| Direction B: | East |
| Terminus B: | at Iowa state line |
| Previous Type: | SD |
| Previous Route: | 45 |
| Next Type: | SD |
| Next Route: | 47 |
South Dakota Highway 46 is a 105.535miles state highway in South Dakota, United States, that runs west to east across the southeastern part of the state. It begins at the junction of U.S. Highway 18 and U.S. Highway 281 in Pickstown, and runs due east to nearly the Iowa border, before curving south to cross the border and meeting Iowa Highway 10.
South Dakota 46 was established around 1935. Its initial alignment only extended west to U.S. Highway 81. The extension further west occurred around 1960.