| State: | SC |
| Type: | SC |
| Route: | 781 |
| Map Custom: | yes |
| Alternate Name: | Tinker Creek Road |
| Length Mi: | 3.561 |
| Length Ref: | [1] |
| Established: | 1940 |
| Direction A: | West |
| Terminus A: | near the Savannah River Site |
| Direction B: | East |
| Terminus B: | near White Pond |
| Counties: | Aiken |
| Previous Type: | SC |
| Previous Route: | 773 |
| Next Type: | SC |
| Next Route: | 802 |
South Carolina Highway 781 (SC 781) is a 3.561miles primary state highway in the U.S. state of South Carolina. It is used as part of a bypass south of Aiken, between Augusta and Williston, in conjunction with U.S. Route 278 (US 278).
SC 781 is a two-lane rural connector highway between US 278 and US 78.
Established in 1940 as a new primary route, it traversed from SC 28 in Beech Island east to US 78 west of Williston. In 1953, SC 781 was truncated to its current western terminus, replaced by a rerouted SC 28 (later became US 278 in 1965).[2] [3]