| State: | SC |
| Type: | SC |
| Route: | 53 |
| Map: | SC 53 map.svg |
| Length Mi: | 11.900 |
| Length Ref: | [1] |
| Direction A: | South |
| Terminus A: | southwest of Shiloh |
| Junction: | in Shiloh northeast of Shiloh |
| Direction B: | North |
| Terminus B: | northeast of Shiloh |
| Counties: | Sumter |
| Previous Type: | US |
| Previous Route: | 52 |
| Next Type: | SC |
| Next Route: | 55 |
South Carolina Highway 53 (SC 53) is a 11.9adj=midNaNadj=mid state highway in the U.S. state of South Carolina. The highway connects Shiloh with rural areas of Sumter County.
SC 53 begins at an intersection with US 378 (Myrtle Beach Highway) southwest of Shiloh, within Sumter County. It travels to the northeast, through rural areas of the county, and curves to a nearly due east direction. It intersects SC 58 (Pleasant Grove Road), and the two highways begin a concurrency. They have an interchange with Interstate 95 (I-95), where they enter Shiloh. Approximately 500feet later, SC 53 splits off to the south, onto Pudding Swamp Road. SC 53 continues through rural areas of the county to an intersection with SC 341 (Mt. Zion Road). About 2000feet later is the highway's northern terminus, an intersection with SC 403 (Lynches River Road/Amwell Church Road). This is southwest of the Lynches River.
| State: | SC |
| Type: | SC 1920-Alt |
| Route: | 53 |
| Location: | Hobbs Crossroads |
| Formed: | 1938 |
| Deleted: | 1947 |
South Carolina Highway 53 Alternate (SC 53 Alt.) was an alternate route that existed partially in Hobbs Crossroads. In May 1938, it was established from SC 341 south-southwest of the community, north-northeast to SC 53 and SC 309 in the community, then west-northwest and northwest back to SC 341. In 1947, it was decommissioned. Today, it is known as Amwell Church Road and Lynches River Road.