| State: | SC |
| Type: | SC 1920 |
| Route: | 50 |
| Established: | 1942 |
| Decommissioned: | 1947 |
| Direction A: | West |
| Terminus A: | in Rock Hill |
| Direction B: | East |
| Terminus B: | Mill Street in Rock Hill |
| Counties: | York |
| Previous Type: | SC |
| Previous Route: | 49 |
| Next Type: | SC |
| Next Route: | 51 |
South Carolina Highway 50 (SC 50) was a state highway that existed in the central part of Orangeburg County. It connected Cordova and Orangeburg.
SC 50 began at an intersection with U.S. Route 21 (US 21) and SC 5 (now Oakland Avenue) in Rock Hill. It traveled to the east on Cedar Street, crossed over a railroad line, and traveled on Curtis Street to end at Mill Street.
SC 50 was established by 1943. It was decommissioned in 1947. It was downgraded to secondary roads.