| State: | SC |
| Type: | SC |
| Route: | 461 |
| Map Custom: | yes |
| Length Mi: | 3.710 |
| Length Ref: | [1] |
| Direction A: | South |
| Terminus A: | in Charleston, South Carolina |
| Junction: | in Charleston |
| Direction B: | North |
| Terminus B: | Bees Ferry Road in Charleston |
| Counties: | Charleston |
| Previous Type: | SC |
| Previous Route: | 460 |
| Next Type: | SC |
| Next Route: | 462 |
South Carolina Highway 461 (SC 461) is a 3.71adj=midNaNadj=mid state highway in the U.S. state of South Carolina. The highway is completely within the West Ashley portion of Charleston.
SC 461 begins at an intersection with SC 61 (Ashley River Road) in the West Ashley portion of Charleston, Charleston County. Here it is known as Paul Cantrell Boulevard. It travels to the west and immediately curves to the west-northwest before an interchange with Interstate 526 (I-526; Mark Clark Expressway). At an intersection with Magwood Drive, the highway takes on the Glenn McConnell Parkway name. It passes southwest of West Ashley Park and northeast of West Ashley High School. The highway crosses over some railroad tracks just before it meets its northern terminus, an intersection with Bees Ferry Road.