| State: | SC |
| Type: | SC |
| Route: | 400 |
| Map Custom: | yes |
| Length Mi: | 12.440 |
| Length Ref: | [1] |
| Direction A: | West |
| Terminus A: | in Norway |
| Direction B: | East |
| Terminus B: | near Edisto |
| Counties: | Orangeburg |
| Previous Type: | SC |
| Previous Route: | 395 |
| Next Type: | US |
| Next Route: | 401 |
South Carolina Highway 400 (SC 400) is a 12.44adj=midNaNadj=mid state highway in the U.S. state of South Carolina. The highway connects Norway with rural areas of Orangeburg County.
SC 400 begins at an intersection with U.S. Route 321 (US 321) and SC 332 (Savannah Highway/Norway Road) in Norway, Orangeburg County. It travels to the east-southeast and leaves the town limits. The highway curves to the east-northeast and crosses over Deadfall Swamp, Roberts Swamp, and Twomile Swamp before entering Bolen Town. While there, it curves to a more easterly direction. SC 400 heads to the east-northeast again before it meets its eastern terminus, an intersection with SC 4 (Neeses Highway) at a point west of Edisto.