| State: | SC |
| Type: | SC |
| Route: | 389 |
| Map Custom: | yes |
| Length Mi: | 13.730 |
| Length Round: | 3 |
| Length Ref: | [1] [2] |
| Direction A: | West |
| Terminus A: | in Perry |
| Junction: | near Salley |
| Direction B: | East |
| Terminus B: | in Neeses |
| Counties: | Orangeburg, Aiken |
| Previous Type: | SC |
| Previous Route: | 385 |
| Next Type: | SC |
| Next Route: | 391 |
South Carolina Highway 389 (SC 389) is a 13.73adj=midNaNadj=mid state highway in the U.S. state of South Carolina. The highway connects Neeses and Perry.
SC 389 begins at an intersection with SC 39 (West Railroad Avenue/Festival Trail Road) in Perry, within Aiken County. It travels to the southeast, enters Orangeburg County, and intersects SC 394 (Salley Road) at a point northeast of Salley. Less than 1miles later, it intersects SC 3 (Capital Way). The highway continues to the southeast and enters the city limits of Neeses. It curves to the east-northeast and crosses over railroad tracks before meeting its eastern terminus, an intersection with U.S. Route 321 (US 321; Savannah Highway). Here, the roadway continues as Ninety Six Road.