| State: | SC |
| Type: | SC |
| Route: | 363 |
| Map: | SC 363 map.svg |
| Length Mi: | 13.270 |
| Length Ref: | [1] |
| Established: | 1940 |
| Direction A: | West |
| Terminus A: | north of Luray |
| Junction: |
|
| Direction B: | East |
| Terminus B: | near Varnville |
| Counties: | Hampton |
| Previous Type: | SC |
| Previous Route: | 362 |
| Next Type: | SC |
| Next Route: | 375 |
South Carolina Highway 363 (SC 363) is a 13.27adj=midNaNadj=mid state highway in the U.S. state of South Carolina. The highway is designated on an east–west direction, from U.S. Route 321 (US 321) in Luray to SC 63 just outside Varnville.