| State: | SC |
| Type: | SC |
| Route: | 146 |
| Map: | SC 146 map.svg |
| Length Mi: | 33.447 |
| Length Ref: | [1] [2] |
| Established: | 1942 |
| Direction A: | West |
| Terminus A: | in Greenville |
| Junction: |
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| Direction B: | East |
| Terminus B: | in Cross Anchor |
| Counties: | Greenville, Spartanburg |
| Previous Type: | SC |
| Previous Route: | 145 |
| Next Type: | SC |
| Next Route: | 150 |
South Carolina Highway 146 (SC 146) is a 33.447miles South Carolina state highway running through Central Greenville County and south-western Spartanburg County.
SC 146's western terminus is at Laurens Road (U.S. Route 276 or US 276), near the intersection of Interstates 85 (I-85) and 385. Its course then goes in a southeasterly direction where its eastern terminus is at its intersection with SC 56 near Cross Anchor.
From its western terminus to its split from SC 417, SC 146 is known as Woodruff Road. From its split to the merger with SC 101, SC 146 is known as 3rd Street. Once SC 146/SC 101 merges with US 221 in Woodruff it is known as Main Street, then Laurens Road as it splits from SC 101. Its final name change happens when SC 146 splits from US 221 just outside Woodruff; its name changes to Cross Anchor Highway, and it keeps that name until it reaches its eastern terminus.