| State: | SC |
| Type: | SC |
| Route: | 110 |
| Map: | SC 110 map.svg |
| Alternate Name: | Battleground Road |
| Established: | 1949 |
| Length Mi: | 9.280 |
| Length Round: | 3 |
| Length Ref: | [1] [2] |
| Tourist: | Cowpens N.B. Scenic Byway |
| Direction A: | West |
| Terminus A: | in Cowpens |
| Junction: | near Cowpens |
| Direction B: | East |
| Terminus B: | near Chesnee |
| Counties: | Spartanburg, Cherokee |
| Previous Type: | SC |
| Previous Route: | 109 |
| Next Type: | SC |
| Next Route: | 113 |
South Carolina Highway 110 (SC 110) is a state highway in the U.S. state of South Carolina that travels 9.28miles from US 29 in Cowpens to US 221 Alt and SC 11 at Cowpens National Battlefield near Chesnee. It is signed and internally designated as an east–west highway though it runs north–south physically.
SC 110 is a two-lane rural highway with relatively few intersections. The highway is named Battleground Road for the entire length. A section east of Mayo is also known as Cowpens Highway. The highway passes next to and ends at Cowpens National Battlefield.
The original SC 110 was created in 1936, running from US 221 in Chesnee north to the North Carolina border, where the road became the now-defunct NC 741. In 1942, the highway was renumbered as a part of US 221. The highway was resurrected in 1949 in its near-current form. When US 29, now I-85, was established in the mid-1950s, the highway was rerouted slightly to the west.