| Official Name: | South Cairo, New York |
| Settlement Type: | Hamlet and CDP |
| Pushpin Map: | New York#USA |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | New York |
| Subdivision Type2: | County |
| Subdivision Name2: | Greene |
| Population As Of: | 2020 |
| Population Total: | 590 |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 200 |
| Coordinates: | 42.2769°N -73.9567°W |
| Postal Code Type: | ZIP code |
| Postal Code: | 12482 |
| Area Code: | 518 & 838 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 965717 |
South Cairo is a hamlet (and census-designated place). It has 590 people, as of the 2020 census.[1] It is situated in Greene County, New York, United States. The community is located along Catskill Creek and New York State Route 23, northwest of Catskill.
South Cairo has a post office with ZIP code 12482.[2] [3]