| South Branch Meduxnekeag River | |
| Mouth Coordinates: | 46.1024°N -67.8712°W |
| Subdivision Type1: | Country |
| Progression: | Meduxnekeag — St. John — |
The South Branch Meduxnekeag River is a 15.2adj=midNaNadj=mid[1] river in Aroostook County, Maine. From the outflow of Johnson Pond (46.0353°N -67.921°W) in Linneus, the river runs about southeast to Cary, before running into the Lt. Gordon Manuel Wildlife Management Area in Hodgdon, then north about to its confluence with the Meduxnekeag River at Carys Mills, two miles upstream from Houlton.