| Official Name: | South Berwick, Maine |
| Settlement Type: | Census-designated place |
| Pushpin Map: | Maine#USA |
| Pushpin Label: | South Berwick |
| Coordinates: | 43.2339°N -70.8086°W |
| Subdivision Type: | Country |
| Subdivision Type1: | State |
| Subdivision Name1: | Maine |
| Subdivision Type2: | County |
| Subdivision Name2: | York |
| Subdivision Type3: | Town |
| Subdivision Name3: | South Berwick |
| Area Footnotes: | [1] |
| Area Total Sq Mi: | 2.82 |
| Area Land Sq Mi: | 2.74 |
| Area Water Sq Mi: | 0.07 |
| Area Total Km2: | 7.30 |
| Area Land Km2: | 7.11 |
| Area Water Km2: | 0.19 |
| Population As Of: | 2020 |
| Population Density Km2: | 538.21 |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 110 |
| Postal Code Type: | ZIP Code |
| Postal Code: | 03908 |
| Area Code: | 207 |
| Blank Name: | FIPS code |
| Blank Info: | 23-69995 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2806296 |
| Population Total: | 3825 |
| Unit Pref: | Imperial |
| Population Density Sq Mi: | 1393.95 |
South Berwick is a census-designated place (CDP) and the primary village in the town of South Berwick, York County, Maine, United States. It is in southwestern York County, in the northwestern corner of the town of South Berwick. It is bordered to the north by the town of Berwick, and to the southwest, across the Salmon Falls River, by the town of Rollinsford, New Hampshire.
Maine State Route 4 passes through the center of the village, leading north-northeast to Sanford, and southwest across the Salmon Falls River, where New Hampshire Route 4 continues 4miles to the city of Dover. State Route 236 leads northwest four miles to Berwick village and south to Kittery.
South Berwick was first listed as a CDP prior to the 2020 census.