| Symbol: | BAR3-WASP |
| WASP-binding domain of Sorting nexin protein | |
| Pfam: | PF10456 |
Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain (a phospholipid-binding motif) or through protein–protein interactions with membrane-associated protein complexes[1] [2] Some members of this family have been shown to facilitate protein sorting.
In humans, sorting nexins are transcribed from the following genes:
| Genes | Domain Composition | |||||
|---|---|---|---|---|---|---|
| N-terminus | Mid-1 | Mid-2 | Mid-3 | C-terminus | ||
| SNX1, SNX2 | Sorting_nexin_N | – | PX | – | BAR[3] (Vps5) | |
| SNX4, SNX7, SNX8, SNX30 | – | – | PX | – | BAR (Vsp5) | |
| SNX5, SNX6, SNX32 | – | – | PX | – | BAR | |
| SNX9, SNX18, SNX33 | SH3 | – | PX | – | BAR (BAR_3_WASP_bdg)[4] | |
| SNX13, SNX14, SNX19, SNX25 | PXA[5] | RGS | PX | – | Nexin_C | |
| SNX15 | – | – | PX | – | MIT[6] | |
| SNX17, SNX31 | – | – | PX | RA[7] | FERM_M[8] | |
| SNX23 | kinesin_motor | SMAD_FHA[9] | PX | – | – | |
| SNX26 | – | – | PX | SH3 | RhoGAP | |
| SNX27 | PDZ | – | PX | - | FERM_M[10] | |
| SNX28 | – | – | PX | SH3 | SH3 | |
| – | – | PX | – | – | ||
Sorting nexins either consist solely of a PX domain (e.g. SNX3) or have a modular structure made up of the PX and additional domains.
A subgroup of sorting nexins (comprising, in humans, SNX1, SNX2, SNX4, SNX5, SNX6, SNX7, SNX8, SNX9, SNX18, SNX30, SNX32 and SNX33) possess a BAR domain at their C-terminus. (The BAR domain of SNXs 1, 2, 4, 7, 8 and 30 is classified by pfam as 'Vps5 C terminal like'.)
An example of a sorting nexin domain structure can be seen here for SNX1: