| Sophie of Württemberg | |
| Consort: | yes |
| Succession: | Duchess consort of Saxe-Weimar |
| Reign: | 1583-1590 |
| House: | House of Württemberg |
| Father: | Christoph, Duke of Württemberg |
| Mother: | Anna Maria of Brandenburg-Ansbach |
| Issue: | Dorothea Sophia, Abbess of Quedlinburg Princess Anna Marie |
| Birth Date: | 20 November 1563 |
| Birth Place: | Stuttgart |
| Death Place: | Vacha |
Sophie of Württemberg (20 November 1563 - 21 July 1590), was a German noblewoman member of the House of Württemberg and by marriage Duchess of Saxe-Weimar.
Born in Stuttgart, she was the youngest of twelve children born from the marriage of Christoph, Duke of Württemberg and Anna Maria of Brandenburg-Ansbach. From her eleven older siblings, nine survive adulthood: Eberhard, Hereditary Prince of Württemberg, Hedwig (by marriage Landgravine of Hesse-Marburg), Elisabeth (by her two marriages Countess of Henneberg-Schleusingen and Countess Palatine of Veldenz-Lauterecken), Sabine (by marriage Landgravine of Hesse-Kassel), Emilie (by marriage Countess Palatine of Simmern-Sponheim), Eleonore (by her two marriages Princess of Anhalt and Landgravine of Hesse-Darmstadt), Louis III, Duke of Württemberg, Dorothea Maria (by marriage Countess Palatine of Sulzbach) and Anna (by her two marriages Duchess of Oława and Legnica).
In Weimar on 5 May 1583 Sophie married Frederick William I, Duke of Saxe-Weimar. They had six children, of whom only two survive adulthood:
Sophie died in Vacha aged 26, following complications of her last childbirth. She was buried in the Stadtkirche St.Peter und Paul, Weimar.
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