| Consort: | yes |
| Succession: | Landgravine consort of Hesse-Darmstadt |
| Reign: | 1 April 1627 – 11 June 1661 |
| Birth Date: | 23 November 1609 |
| Father: | John George I, Elector of Saxony |
| Issue: | Louis VI, Landgrave of Hesse-Darmstadt George III, Landgrave of Hesse-Itter Elisabeth Amalie, Electress Palatine Sophia Eleonore, Landgravine of Hesse-Homburg Louise Christine, Countess of Stolberg-Stolberg Anna Sophia, Abbess of Quedlinburg Marie Hedwig, Duchess of Saxe-Meiningen |
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| Mother: | Magdalene Sibylle of Prussia |
| House: | Wettin |
Sophia Eleonore of Saxony (23 November 1609 - 2 June 1671) was a duchess of Saxony by birth and the landgravine of Hesse-Darmstadt from 1627 to 1661 through her marriage to Landgrave George II. She was the eldest surviving child of John George I, Elector of Saxony, and Magdalene Sibylle of Prussia.
She was born in Dresden. Her two sisters were Marie Elisabeth and Magdalene Sibylle. Her brothers were Johann Georg, August, Christian, and Maurice.
She married Landgrave Georg II of Hesse-Darmstadt on 1 April 1627 in Torgau, aged seventeen. In the middle of Thirty Years' War their marriage was lavishly celebrated with the first opera in German language Dafne. They had fifteen children; she raised them as strict Lutherans. However, her daughter Elisabeth Amalie, later Electress Palatine, converted to Roman Catholicism in 1653.
Sophie Eleonore showed huge interest in antiquarian books which she collected. Her contribution to the Hesse-Darmstadt court library is still visible today. She survived her husband by ten years and died in Darmstadt.
She had the following children with George II, Landgrave of Hesse-Darmstadt:
Sophie Eleonore also suffered four miscarriages:
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