Somatostatin receptor 1 explained

Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene.^{[1] [2]}

Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach.

See also

• Somatostatin receptor

Further reading

• Yamada Y, Post SR, Wang K, Tager HS, Bell GI, Seino S . Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney . Proceedings of the National Academy of Sciences of the United States of America . 89 . 1 . 251–5 . January 1992 . 1346068 . 48214 . 10.1073/pnas.89.1.251 . 1992PNAS...89..251Y . free .
• Fujita T, Yamaji Y, Sato M, Murao K, Takahara J . Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines . Life Sciences . 55 . 23 . 1797–806 . 1994 . 7968260 . 10.1016/0024-3205(94)90090-6 .
• Kaupmann K, Bruns C, Hoyer D, Seuwen K, Lübbert H . Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain . FEBS Letters . 331 . 1–2 . 53–9 . September 1993 . 8405411 . 10.1016/0014-5793(93)80296-7 . 22557713 . free .
• Le Romancer M, Cherifi Y, Levasseur S, Laigneau JP, Peranzi G, Jais P, Lewin MJ, Reyl-Desmars F . Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae . Life Sciences . 58 . 13 . 1091–8 . 1996 . 8622562 . 10.1016/0024-3205(96)00063-X .
• Fukusumi S, Kitada C, Takekawa S, Kizawa H, Sakamoto J, Miyamoto M, Hinuma S, Kitano K, Fujino M . Identification and characterization of a novel human cortistatin-like peptide . Biochemical and Biophysical Research Communications . 232 . 1 . 157–63 . March 1997 . 9125122 . 10.1006/bbrc.1997.6252 .
• de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, Sutcliffe JG . Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin . Genomics . 42 . 3 . 499–506 . June 1997 . 9205124 . 10.1006/geno.1997.4763 . 24935564 .
• Jaïs P, Terris B, Ruszniewski P, LeRomancer M, Reyl-Desmars F, Vissuzaine C, Cadiot G, Mignon M, Lewin MJ . Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours . European Journal of Clinical Investigation . 27 . 8 . 639–44 . August 1997 . 9279525 . 10.1046/j.1365-2362.1997.1740719.x . 23503397 .
• Ferone D, van Hagen PM, van Koetsveld PM, Zuijderwijk J, Mooy DM, Lichtenauer-Kaligis EG, Colao A, Bogers AJ, Lombardi G, Lamberts SW, Hofland LJ . In vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cells . Endocrinology . 140 . 1 . 373–80 . January 1999 . 9886848 . 10.1210/endo.140.1.6398 . free .
• Kumar U, Sasi R, Suresh S, Patel A, Thangaraju M, Metrakos P, Patel SC, Patel YC . Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis . Diabetes . 48 . 1 . 77–85 . January 1999 . 9892225 . 10.2337/diabetes.48.1.77 .
• Rocheville M, Lange DC, Kumar U, Sasi R, Patel RC, Patel YC . Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers . The Journal of Biological Chemistry . 275 . 11 . 7862–9 . March 2000 . 10713101 . 10.1074/jbc.275.11.7862 . free .
• Schwärzler A, Kreienkamp HJ, Richter D . Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast . The Journal of Biological Chemistry . 275 . 13 . 9557–62 . March 2000 . 10734105 . 10.1074/jbc.275.13.9557 . free .
• Zatelli MC, Tagliati F, Taylor JE, Rossi R, Culler MD, degli Uberti EC . Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt . The Journal of Clinical Endocrinology and Metabolism . 86 . 5 . 2161–9 . May 2001 . 10.1210/jcem.86.5.7489 . 11344221 . free .
• Klisovic DD, O'Dorisio MS, Katz SE, Sall JW, Balster D, O'Dorisio TM, Craig E, Lubow M . Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study . Investigative Ophthalmology & Visual Science . 42 . 10 . 2193–201 . September 2001 . 11527930 .
• Pasquali D, Notaro A, Esposito D, Vassallo P, Bonavolontà G, Bellastella A, Sinisi AA . [Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy] . Minerva Endocrinologica . 26 . 3 . 175–9 . September 2001 . 11753241 .
• Papotti M, Bongiovanni M, Volante M, Allìa E, Landolfi S, Helboe L, Schindler M, Cole SL, Bussolati G . Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis . Virchows Archiv . 440 . 5 . 461–75 . May 2002 . 12021920 . 10.1007/s00428-002-0609-x . 28584328 .
• Zatelli MC, Tagliati F, Piccin D, Taylor JE, Culler MD, Bondanelli M, degli Uberti EC . Somatostatin receptor subtype 1-selective activation reduces cell growth and calcitonin secretion in a human medullary thyroid carcinoma cell line . Biochemical and Biophysical Research Communications . 297 . 4 . 828–34 . October 2002 . 12359227 . 10.1016/S0006-291X(02)02307-0 .
• Ferone D, Pivonello R, Van Hagen PM, Dalm VA, Lichtenauer-Kaligis EG, Waaijers M, Van Koetsveld PM, Mooy DM, Colao A, Minuto F, Lamberts SW, Hofland LJ . Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes . American Journal of Physiology. Endocrinology and Metabolism . 283 . 5 . E1056-66 . November 2002 . 12376335 . 10.1152/ajpendo.00205.2001 . 10.1.1.945.8926 .
• Pasquali D, Notaro A, Bonavolonta' G, Vassallo P, Bellastella A, Sinisi AA . Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease . The Journal of Clinical Endocrinology and Metabolism . 87 . 11 . 5125–9 . November 2002 . 12414882 . 10.1210/jc.2002-020790 . free .
• Dizeyi N, Konrad L, Bjartell A, Wu H, Gadaleanu V, Hansson J, Helboe L, Abrahamsson PA . Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines . Urologic Oncology . 7 . 3 . 91–8 . 2002 . 12474541 . 10.1016/S1078-1439(01)00173-9 .

External links

• Web site: Somatostatin Receptors: sst₁ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2016-03-03 . https://web.archive.org/web/20160303204852/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2439 . dead .

Notes and References

1. Yamada Y, Stoffel M, Espinosa R, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI . Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms . Genomics . 15 . 2 . 449–52 . February 1993 . 8449518 . 10.1006/geno.1993.1088 .
2. Web site: Entrez Gene: SSTR1 somatostatin receptor 1.