SomaLogic explained

SomaLogic, Inc.
Traded As:NASDAQ:
Industry:Health information
Founder:Larry Gold
Fate:Merged with Standard BioTools
Hq Location City:Boulder, Colorado
Hq Location Country:United States

SomaLogic, Inc. is a protein biomarker discovery and clinical diagnostics company[1] located in Boulder, Colorado. It became listed on Nasdaq in September 2021 with a merger with the special-purpose acquisition company CM Life Sciences II, Inc.[2] The company was acquired by Standard BioTools in January 2024 in an all-stock deal.[3]

History

SomaLogic was founded in 2000 by Larry Gold, who served as both Chairman of the Board of Directors and as the company’s first CEO. In 2013, Byron Hewett was appointed as CEO,[4] with Gold continuing to serve as Chairman.[5] Gold previously founded the pharmaceutical company NeXstar Pharmaceuticals, which merged with Gilead in 1999.[6] Hewett stepped down in 2017 and board member Alister Reynolds was appointed the new CEO,[7] who was replaced by Roy Smythe in 2018.[8]

In July 2022, SomaLogic agreed to acquire Palamedrix Inc, DNA nanotechnology company. [9]

Systems

SomaLogic monitors health and disease through the analysis of protein concentration changes in biological samples.[10] They developed the SomaScan platform, which allows scientists and researchers to identify protein biomarkers for diseases and conditions, and apply them to drug and diagnostic research and development.[11] The hypothesis behind the analysis is that different diseases and conditions each have novel protein profiles, including in early stages of onset. As of 2013, the commercial version of the SomaScan platform could identify and quantify 1,129 protein analytes simultaneously. As of 2017, the number had increased to about 4,200.[12] The platform is based on modified-aptamer binding technology (“SOMAmers”) that bind to their respective target proteins in order to determine their presence and quantity in a sample.[13] [14] [15]

Partnerships

In 2013, SomaLogic partnered with Agilent Technologies to distribute SomaScan systems to American research and educational institutions. It also signed a development deal with Quest Diagnostics to create a blood test for early-stage, non-small-cell lung cancer.[16] [17] It also has partnerships with Otsuka and New England Biolabs.[18] In 2016, a study was published that used the SomaLogic system to identify nine biomarker proteins that could predict the risk of a second heart attack in those who have suffered a previous cardiovascular event.[19] A study in Circulation also used the 9-protein cardiovascular risk score for early detection of the harmful effects of Torcetrapib.[20] In 2016 they also developed a test to diagnose latent tuberculosis, and to predict the progression of the disease after onset.[21] In 2019, a study was published that used the SomaScan platform to build protein-based models for 11 different health indications: liver fat, kidney filtration, percentage body fat, visceral fat mass, lean body mass, cardiopulmonary fitness, physical activity, alcohol consumption, cigarette smoking, diabetes risk, and primary cardiovascular event risk.[22]

SomaLogic has a long-term partnership with the Novartis Institutes for BioMedical Research, with Novartis taking an ownership stake in SomaLogic in 2014 as a part of the extension of their initial agreement. In 2016, SomaLogic formed a collaborative partnership with Oxford University,[23] and in 2017, it joined the iCarbonX Digital Life Alliance (including an investment by iCarbonX in SomaLogic).[24]

In 2018, SomaLogic teamed up with the Leeds Centre for Personalised Health and Medicine to test the SomaScan platform in clinical studies in the UK.[25] That same year, SomaLogic also began to package its insights as diagnostic information for sale to other companies, focusing on proteomic data.[26] In 2019, SomaLogic entered into a new 10-year agreement with Novartis to use the SomaScan proteomics technology in drug discovery and development efforts.[27] Also that year, SomaLogic began commercially offering health information tests on the SomaScan Platform to prescribing physicians in Colorado.[28] In 2020, NEC Solution Innovators, Ltd. of Japan, a subsidiary of NEC Corporation, launched a new company, FonesLife Corporation, that will collaborate with SomaLogic to bring proteomic-based health monitoring tests to people in Japan.[29]

Notes and References

  1. Web site: Term Sheet — Tuesday, March 1. Fortune.com. 26 November 2017.
  2. SomaLogic Closes Business Combination and Will Begin Trading Under the Ticker "SLGC" on the Nasdaq Stock Exchange . . September 1, 2021.
  3. Standard BioTools and SomaLogic to Combine in All-Stock Merger Creating a Diversified Leader in Life Sciences Tools . October 4, 2023 . GlobeNewswire.
  4. Web site: INterview with Bryron Hewett, CEO of SomaLogic. 26 January 2016. Innovationsews.com. 26 November 2017.
  5. Web site: SomaLogic Names New CEO; Founder Larry Gold to Stay on as Chairman - Xconomy. 3 December 2013. Xconomy.com. 26 November 2017.
  6. Web site: Gilead Sciences and NeXstar Pharmaceuticals to Merge - Gilead. Gilead.com. 26 November 2017.
  7. Web site: People in the News: Alister Reynolds, Erik Phelps, and James Heath. 26 November 2017.
  8. Web site: Slone Partners Finds New CEO for SomaLogic. 3 December 2018.
  9. Web site: 2022-07-26 . SomaLogic to Acquire DNA Nanotech Firm Palamedrix for up to $52.5M . 2022-07-26 . Genomeweb . en.
  10. Web site: PatientsLikeMe Nabs $100M, Works to Advance Personalized Medicine - Xconomy. 6 January 2017. Xconomy.com. 26 November 2017.
  11. Web site: Somalogic Lands Funding After Novartis Extends. Bizjournals.com. 26 November 2017.
  12. Cyranoski . David . Chinese AI company plans to mine health data faster than rivals . Nature . 12 January 2017 . 541 . 7636 . 141–142 . 10.1038/541141a . 28079091 . 2017Natur.541..141C . free .
  13. News: Chi . Kelly Rae . High-Density Info . The Scientist Magazine . March 31, 2014 .
  14. Book: Rastogi . S. C. . Rastogi . Parag . Mendiratta . Namita . Bioinformatics Methods And Applications: Genomics Proteomics And Drug Discovery . 3rd . 2008 . PHI Learning Pvt. Ltd. . 978-81-203-3595-0 . 362 .
  15. Keeney . Tracy R. . Bock . Christopher . Gold . Larry . Kraemer . Stephan . Lollo . Bridget . Nikrad . Malti . Stanton . Martin . Stewart . Alex . Vaught . Jonathan D. . Walker . Jeffrey J. . Automation of the SomaLogic Proteomics Assay: A Platform for Biomarker Discovery . Journal of the Association for Laboratory Automation . December 2009 . 14 . 6 . 360–366 . 10.1016/j.jala.2009.05.003 .
  16. Web site: SomaLogic Partners with Agilent to Distribute Proteomic Technology - Xconomy. 13 August 2013. Xconomy.com. 26 November 2017.
  17. Powell . Kendall . New platform for cataloging hundreds of proteins gets test drive . Nature Medicine . 8 October 2014 . 20 . 10 . 1082–1083 . 10.1038/nm1014-1082 . 25295926 .
  18. Web site: People to Watch : Larry Gold. Bizjournals.com. 26 November 2017.
  19. Ganz . Peter . Heidecker . Bettina . Hveem . Kristian . Jonasson . Christian . Kato . Shintaro . Segal . Mark R. . Sterling . David G. . Williams . Stephen A. . Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease . JAMA . 21 June 2016 . 315 . 23 . 2532–41 . 10.1001/jama.2016.5951 . 27327800 . free .
  20. Williams . Stephen A. . Murthy . Ashwin C. . DeLisle . Robert K. . Hyde . Craig . Malarstig . Anders . Ostroff . Rachel . Weiss . Sophie J. . Segal . Mark R. . Ganz . Peter . Improving Assessment of Drug Safety Through Proteomics . Circulation . 6 March 2018 . 137 . 10 . 999–1010 . 10.1161/CIRCULATIONAHA.117.028213 . 28974520 . 5839936 .
  21. Web site: SomaLogic Developing Tests to Diagnose Latent Tuberculosis, Predict Progression. Genomeweb.com. 26 November 2017.
  22. Williams . Stephen A. . Kivimaki . Mika . Langenberg . Claudia . Hingorani . Aroon D. . Casas . J. P. . Bouchard . Claude . Jonasson . Christian . Sarzynski . Mark A. . Shipley . Martin J. . Alexander . Leigh . Ash . Jessica . Bauer . Tim . Chadwick . Jessica . Datta . Gargi . DeLisle . Robert Kirk . Hagar . Yolanda . Hinterberg . Michael . Ostroff . Rachel . Weiss . Sophie . Ganz . Peter . Wareham . Nicholas J. . Plasma protein patterns as comprehensive indicators of health . Nature Medicine . December 2019 . 25 . 12 . 1851–1857 . 10.1038/s41591-019-0665-2 . 31792462 . 6922049 .
  23. News: University and SomaLogic announce agreement for discovery . University of Oxford . 8 February 2016 .
  24. Web site: China's iCarbonX Invests in SomaLogic, Grows Medical Data Alliance. Genomeweb.com. 26 November 2017.
  25. Web site: Boulder's SomaLogic to partner with UK medical center . Daily Camera Boulder . February 8, 2018 .
  26. Web site: Somalogic Exploring New Models for Selling Clinical Products Based on SomaScan System . GenomeWeb . January 18, 2018 . Adam Bonislawski.
  27. “SomaLogic Expands Agreement with Novartis” genomeweb.com. 21 October 2019.https://www.genomeweb.com/proteomics-protein-research/somalogic-expands-agreement-novartis#.XzLRyRNKi-o
  28. Web site: SomaLogic launches its firsts SomaSignal tests in Colorado. 5 September 2019.
  29. “NEC Company Collaborating with Somalogic on Proteomics-Based Health Monitoring” 360dx.com. 10 July 2020.https://www.360dx.com/business-news/nec-company-collaborating-somalogic-proteomics-based-health-monitoring#.XzLWhhNKi-o

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