Solute carrier organic anion transporter family member 1B1 explained

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.^{[1] [2]} Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin.^[3] Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.^[4]

See also

• Solute carrier family

References

Further reading

• Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG . A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters . J. Biol. Chem. . 274 . 52 . 37161–8 . 2000 . 10601278 . 10.1074/jbc.274.52.37161 . free.
• König J, Cui Y, Nies AT, Keppler D . A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane . Am. J. Physiol. Gastrointest. Liver Physiol. . 278 . 1 . G156–64 . 2000 . 10644574 . 10.1152/ajpgi.2000.278.1.G156. 7358020 . free .
• Rollinger-Holzinger I, Eibl B, Pauly M, Griesser U, Hentges F, Auer B, Pall G, Schratzberger P, Niederwieser D, Weiss EH, Zwierzina H . LST1: a gene with extensive alternative splicing and immunomodulatory function . J. Immunol. . 164 . 6 . 3169–76 . 2000 . 10706707 . 10.4049/jimmunol.164.6.3169 . free .
• König J, Cui Y, Nies AT, Keppler D . Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide . J. Biol. Chem. . 275 . 30 . 23161–8 . 2000 . 10779507 . 10.1074/jbc.M001448200 . free .
• Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A . Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family . Biochem. Biophys. Res. Commun. . 273 . 1 . 251–60 . 2000 . 10873595 . 10.1006/bbrc.2000.2922 .
• Cui Y, König J, Leier I, Buchholz U, Keppler D . Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6 . J. Biol. Chem. . 276 . 13 . 9626–30 . 2001 . 11134001 . 10.1074/jbc.M004968200 . free .
• Tirona RG, Leake BF, Merino G, Kim RB . Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans . J. Biol. Chem. . 276 . 38 . 35669–75 . 2001 . 11477075 . 10.1074/jbc.M103792200 . free .
• Jung D, Hagenbuch B, Gresh L, Pontoglio M, Meier PJ, Kullak-Ublick GA . Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha . J. Biol. Chem. . 276 . 40 . 37206–14 . 2001 . 11483603 . 10.1074/jbc.M103988200 . free .
• Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T . Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis . J. Pharmacol. Exp. Ther. . 302 . 2 . 804–13 . 2002 . 12130747 . 10.1124/jpet.302.2.804 .
• Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM, Klein K, Eichelbaum M, Keppler D, Konig J . A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter . J. Biol. Chem. . 277 . 45 . 43058–63 . 2003 . 12196548 . 10.1074/jbc.M207735200 . free .
• Tirona RG, Leake BF, Wolkoff AW, Kim RB . Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation . J. Pharmacol. Exp. Ther. . 304 . 1 . 223–8 . 2003 . 12490595 . 10.1124/jpet.102.043026 . 1475068 .
• Wang P, Kim RB, Chowdhury JR, Wolkoff AW . The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport . J. Biol. Chem. . 278 . 23 . 20695–9 . 2003 . 12670950 . 10.1074/jbc.M301100200 . free .
• Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, Kusuhara H, Urasaki Y, Urae A, Higuchi S, Otsubo K, Sugiyama Y . Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics . Clin. Pharmacol. Ther. . 73 . 6 . 554–65 . 2003 . 12811365 . 10.1016/S0009-9236(03)00060-2 . 6570648 .
• Niemi M, Schaeffeler E, Lang T, Fromm MF, Neuvonen M, Kyrklund C, Backman JT, Kerb R, Schwab M, Neuvonen PJ, Eichelbaum M, Kivistö KT . High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1) . Pharmacogenetics . 14 . 7 . 429–40 . 2005 . 15226675 . 10.1097/01.fpc.0000114750.08559.32 .
• Huang MJ, Kua KE, Teng HC, Tang KS, Weng HW, Huang CS . Risk factors for severe hyperbilirubinemia in neonates . Pediatr. Res. . 56 . 5 . 682–9 . 2005 . 15319464 . 10.1203/01.PDR.0000141846.37253.AF . free .
• Campbell SD, de Morais SM, Xu JJ . Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia . Chem. Biol. Interact. . 150 . 2 . 179–87 . 2005 . 15535988 . 10.1016/j.cbi.2004.08.008 .
• Huang CS, Huang MJ, Lin MS, Yang SS, Teng HC, Tang KS . Genetic factors related to unconjugated hyperbilirubinemia amongst adults . Pharmacogenet. Genomics . 15 . 1 . 43–50 . 2005 . 15864125 . 10.1097/01213011-200501000-00007 . 24247125 .
• Katz DA, Carr R, Grimm DR, Xiong H, Holley-Shanks R, Mueller T, Leake B, Wang Q, Han L, Wang PG, Edeki T, Sahelijo L, Doan T, Allen A, Spear BB, Kim RB . Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics . Clin. Pharmacol. Ther. . 79 . 3 . 186–96 . 2006 . 16513443 . 10.1016/j.clpt.2005.11.003 . 21496707 .

Notes and References

1. Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H . Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 . J Biol Chem . 274 . 24 . 17159–63 . Jul 1999 . 10358072 . 10.1074/jbc.274.24.17159 . free .
2. Web site: Entrez Gene: SLCO1B1 solute carrier organic anion transporter family, member 1B1.
3. Carr DF, O'Meara H, Jorgensen AL, Campbell J, Hobbs M, McCann G, van Staa T, Pirmohamed M . SLCO1B1 Genetic Variant Associated with Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink . Clinical Pharmacology & Therapeutics . 94 . 6 . 695–701 . 2013 . 23942138 . 3831180 . 10.1038/clpt.2013.161 .
4. Huser V, Cimino JJ . Providing pharmacogenomics clinical decision support using whole genome sequencing data as input . AMIA Summits on Translational Science Proceedings AMIA Summit on Translational Science . 2013 . 81 . 2013 . 24303303 .