SLC22A11 explained

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.^{[1] [2] [3] [4]}

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.

See also

• Solute carrier family

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Sun W, Wu RR, van Poelje PD, Erion MD . Isolation of a family of organic anion transporters from human liver and kidney . Biochem. Biophys. Res. Commun. . 283 . 2 . 417–22 . 2001 . 11327718 . 10.1006/bbrc.2001.4774 .
• Babu E, Takeda M, Narikawa S, etal . Human organic anion transporters mediate the transport of tetracycline . Jpn. J. Pharmacol. . 88 . 1 . 69–76 . 2002 . 11855680 . 10.1254/jjp.88.69 . free .
• Kimura H, Takeda M, Narikawa S, etal . Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins . J. Pharmacol. Exp. Ther. . 301 . 1 . 293–8 . 2002 . 11907186 . 10.1124/jpet.301.1.293 . 7739298 .
• Takeda M, Babu E, Narikawa S, Endou H . Interaction of human organic anion transporters with various cephalosporin antibiotics . Eur. J. Pharmacol. . 438 . 3 . 137–42 . 2002 . 11909604 . 10.1016/S0014-2999(02)01306-7 .
• Enomoto A, Takeda M, Shimoda M, etal . Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors . J. Pharmacol. Exp. Ther. . 301 . 3 . 797–802 . 2002 . 12023506 . 10.1124/jpet.301.3.797 .
• Enomoto A, Kimura H, Chairoungdua A, etal . Molecular identification of a renal urate anion exchanger that regulates blood urate levels . Nature . 417 . 6887 . 447–52 . 2002 . 12024214 . 10.1038/nature742 . 2002Natur.417..447E . 4417844 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Zhou F, Tanaka K, Pan Z, etal . The role of glycine residues in the function of human organic anion transporter 4 . Mol. Pharmacol. . 65 . 5 . 1141–7 . 2004 . 15102942 . 10.1124/mol.65.5.1141 .
• Zhou F, Pan Z, Ma J, You G . Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4) . Biochem. J. . 384 . Pt 1 . 87–92 . 2005 . 15291761 . 10.1042/BJ20040751 . 1134091 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Taylor TD, Noguchi H, Totoki Y, etal . Human chromosome 11 DNA sequence and analysis including novel gene identification . Nature . 440 . 7083 . 497–500 . 2006 . 16554811 . 10.1038/nature04632 . 2006Natur.440..497T . free .

Notes and References

1. Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H . Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta . J Biol Chem . 275 . 6 . 4507–12 . Mar 2000 . 10660625 . 10.1074/jbc.275.6.4507 . free .
2. Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G . The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4 . Mol Pharmacol . 67 . 3 . 868–76 . Feb 2005 . 15576633 . 10.1124/mol.104.007583 . 7477352 .
3. Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A . Human renal organic anion transporter 4 operates as an asymmetric urate transporter . J Am Soc Nephrol . 18 . 2 . 430–9 . Jan 2007 . 17229912 . 10.1681/ASN.2006040415 . free .
4. Web site: Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11.