Solamargine Explained

Solamargine is a cytotoxic chemical compound that occurs in plants of the family Solanaceae, such as potatoes, tomatoes, and eggplants.^{[1] [2]} It has been also isolated from Solanum nigrum fungal endophyte Aspergillus flavus.^[3] It is a glycoalkaloid derived from the steroidal alkaloid solasodine.

Solamargine was one component of the unsuccessful experimental cancer drug candidate Coramsine.

See also

• Solanum americanum

Notes and References

1. Al Chami, L. . Mendez, R. . Chataing, B. . O'Callaghan, J. . Usubilliga, A. . Lacruz, L. . 3 . Toxicological effects of α-solamargine in experimental animals . Phytotherapy Research . 2003 . 17 . 3 . 254–8 . 10.1002/ptr.1122 . 12672156 . 86042610 . 2009-09-01 . 2012-06-16 . https://web.archive.org/web/20120616095551/http://cat.inist.fr/?aModele=afficheN&cpsidt=14637560 . dead .
2. Blankemeyer . J. T. . McWilliams . M. L. . Rayburn . J. R. . Weissenberg . M. . Friedman . M. . 3. Developmental toxicology of solamargine and solasonine glycoalkaloids in frog embryos . Food and Chemical Toxicology . 1998 . 36 . 5 . 383–9 . 10.1016/s0278-6915(97)00164-6 . 9662413 .
3. El-Hawary. S.s.. Mohammed. R.. AbouZid. S.f.. Bakeer. W.. Ebel. R.. Sayed. A.m.. Rateb. M.e.. 3. 2016-04-01. Solamargine production by a fungal endophyte of Solanum nigrum. Journal of Applied Microbiology. en. 120. 4. 900–911. 10.1111/jam.13077. 26811095. 1365-2672. free.