| Official Name: | Sofia Region |
| Settlement Type: | Region |
| Mapsize: | 180px |
| Subdivision Type: | Country |
| Seat Type: | Capital |
| Seat: | Antsohihy |
| Government Footnotes: | [1] |
| Leader Title: | Governor |
| Leader Name: | René de Rolland Urbain Lylison |
| Area Total Km2: | 50100 |
| Population As Of: | 2018 |
| Population Footnotes: | [2] |
| Population Total: | 1500227 |
| Population Density Km2: | auto |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Timezone: | EAT |
| Utc Offset: | 3 |
| Blank Name Sec1: | HDI (2018) |
| Blank Info Sec1: | 0.538[3] · 6th of 22 |
Sofia is a region in northern Madagascar. It is named for the Sofia River. It is the second largest Malagasy region (behind Atsimo-Andrefana) with an area of 50,100 km² (19,300 sq mi), and had a population of 1,500,227 in 2018.[4] The administrative capital is Antsohihy.
Sofia Region is divided into seven districts, which are sub-divided into 108 communes.
Sofia is crossed by the National Road 4 (Antananarivo-Mahajanga), National Road 6 (Antsohihy-Diego Suarez), the National road 31 (Antsohihy to Mandritsara) and National road 32 (Antsohihy to Bealanana).
Sofia disposes of the highest concentration of mangroves in Madagascar with a total surface of 450 km2.[5]