Sodium channel opener explained

A sodium channel opener is a type of drug which facilitates ion transmission through sodium channels.

Examples include toxins, such as aconitine, veratridine, batrachotoxin, robustoxin, palytoxin and ciguatoxins and insecticides (DDT and pyrethroids), which activate voltage-gated sodium channels (VGSCs), and solnatide (AP301), which activates the epithelial sodium channel (ENaC).^[1]

See also

• Sodium channel blocker

Notes and References

1. Shabbir W, Tzotzos S, Bedak M, Aufy M, Willam A, Kraihammer M, Holzner A, Czikora I, Scherbaum-Hazemi P, Fischer H, Pietschmann H, Fischer B, Lucas R, Lemmens-Gruber R . Glycosylation-dependent activation of epithelial sodium channel by solnatide . Biochem. Pharmacol. . 98. 740–53. 2015 . 4 . 26254591 . 10.1016/j.bcp.2015.08.003 .