Sodium–hydrogen antiporter 2 explained

Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.^[1]

See also

• Solute carrier family

Further reading

• Chow CW . Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3. . Clinical and Investigative Medicine . 22 . 5 . 195–206 . 1999 . 10579058 .
• Kulanthaivel P, Furesz TC, Moe AJ, etal . Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane. . Biochem. J. . 284 . 1. 33–8 . 1992 . 1318024 . 10.1042/bj2840033. 1132693 .
• Collins JF, Honda T, Knobel S, etal . Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2). . Proc. Natl. Acad. Sci. U.S.A. . 90 . 9 . 3938–42 . 1993 . 7683411 . 10.1073/pnas.90.9.3938 . 46421 . 1993PNAS...90.3938C . free .
• Ghishan FK, Knobel SM, Summar M . Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2). . Genomics . 30 . 1 . 25–30 . 1996 . 8595899 . 10.1006/geno.1995.0004 .
• Dudeja PK, Rao DD, Syed I, etal . Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA. . Am. J. Physiol. . 271 . 3 Pt 1 . G483–93 . 1996 . 8843774 . 10.1152/ajpgi.1996.271.3.G483.
• Lin X, Barber DL . A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. . Proc. Natl. Acad. Sci. U.S.A. . 93 . 22 . 12631–6 . 1996 . 8901634 . 10.1073/pnas.93.22.12631 . 38044 . 1996PNAS...9312631L . free .
• Toward a complete human genome sequence. . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. free . Sanger Centre . The . Washington University Genome Sequencing Cente . The .
• Chow CW, Woodside M, Demaurex N, etal . Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia. . J. Biol. Chem. . 274 . 15 . 10481–8 . 1999 . 10187839 . 10.1074/jbc.274.15.10481 . free .
• Malakooti J, Dahdal RY, Schmidt L, etal . Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2. . Am. J. Physiol. . 277 . 2 Pt 1 . G383–90 . 1999 . 10444453 . 10.1152/ajpgi.1999.277.2.G383. 4467617 .
• Malakooti J, Dahdal RY, Dudeja PK, etal . The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization. . Am. J. Physiol. Gastrointest. Liver Physiol. . 280 . 4 . G763–73 . 2001 . 11254504 . 10.1152/ajpgi.2001.280.4.G763. 10642872 .
• Pang T, Su X, Wakabayashi S, Shigekawa M . Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers. . J. Biol. Chem. . 276 . 20 . 17367–72 . 2001 . 11350981 . 10.1074/jbc.M100296200 . free .
• Repishti M, Hogan DL, Pratha V, etal . Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement. . Am. J. Physiol. Gastrointest. Liver Physiol. . 281 . 1 . G159–63 . 2001 . 11408268 . 10.1152/ajpgi.2001.281.1.G159. 616434 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Lacey HA, Nolan T, Greenwood SL, etal . Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR. . Placenta . 26 . 1 . 93–8 . 2005 . 15664417 . 10.1016/j.placenta.2004.05.005 .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Pearse I, Zhu YX, Murray EJ, etal . Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site. . Biochem. J. . 407 . 1 . 101–11 . 2007 . 17561809 . 10.1042/BJ20070364 . 2267401 .

Notes and References

1. Web site: Entrez Gene: SLC9A2 solute carrier family 9 (sodium/hydrogen exchanger), member 2.