Small nucleolar RNA SNORD87 explained

Small nucleolar RNA SNORD87
Symbol:	SNORD87
Altsymbols:	U87
Rfam:	RF00439
Rna Type:	Gene snRNA; snoRNA; C/D-box
Tax Domain:	Eukaryota

In molecular biology, SNORD87 (also known as U87) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryote cell which is a major site of snRNA bio genesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U87 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.^{[1] [2]}

U87 was identified by purification from yeast (Saccharomyces cerevisiae)^[3] and is the orthologue of mouse MBII-276^[4]

Notes and References

1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I . Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro . Molecular and Cellular Biology . 22 . 19 . 6663–8 . October 2002 . 12215523 . 134041 . 10.1128/MCB.22.19.6663-6668.2002 .
2. Kiss T . Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions . Cell . 109 . 2 . 145–8 . April 2002 . 12007400 . 10.1016/S0092-8674(02)00718-3 . 8968788 . free .
3. Gogolevskaya IK, Makarova JA, Gause LN, Kulichkova VA, Konstantinova IM, Kramerov DA . U87 RNA, a novel C/D box small nucleolar RNA from mammalian cells . Gene . 292 . 1–2 . 199–204 . June 2002 . 12119114 . 10.1016/S0378-1119(02)00678-9 . 10.1.1.510.4087 .
4. Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J . RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse . The EMBO Journal . 20 . 11 . 2943–53 . June 2001 . 11387227 . 125495 . 10.1093/emboj/20.11.2943 .