Small nucleolar RNA SNORD73 explained

Small nucleolar RNA SNORD73
Symbol:	SNORD73
Altsymbols:	U73
Rfam:	RF00071
Rna Type:	Gene snRNA; snoRNA; CD-box
Tax Domain:	Eukaryota

In molecular biology, snoRNA U73 (also known as SNORD73) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U73 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.^[1]

U73 is encoded within the introns of ribosomal protein S3a and contains a 12 nucleotide region of complementarity to a conserved sequence in 28S ribosomal RNA (rRNA).^[2] U73 has been demonstrated to function as a 2'-O-ribose methylation guide RNA for pre-28S rRNA.^[3]

Notes and References

1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I . Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro . Molecular and Cellular Biology . 22 . 19 . 6663–8 . October 2002 . 12215523 . 134041 . 10.1128/MCB.22.19.6663-6668.2002 .
2. Rebane A, Tamme R, Laan M, Pata I, Metspalu A . A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes . Gene . 210 . 2 . 255–63 . April 1998 . 9573378 . 10.1016/S0378-1119(98)00070-5 .
3. Rebane A, Roomere H, Metspalu A . Locations of several novel 2'-O-methylated nucleotides in human 28S rRNA . BMC Molecular Biology . 3 . 1 . 2002 . 11897011 . 88882 . 10.1186/1471-2199-3-1 . free .