Small nucleolar RNA SNORA71 explained
| Small nucleolar RNA SNORA71 |
| Symbol: | SNORA71 |
| Altsymbols: | U71 |
| Rfam: | RF00056 |
| Rna Type: | Gene
- snRNA; snoRNA; H/ACA-box
|
| Tax Domain: | Eukaryota |
In molecular biology, U71 belongs to the H/ACA class of Small nucleolar RNA (snoRNAs). snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class are thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs.[1] Targets may include ribosomal and spliceosomal RNAs but the exact function of many snoRNAs, including U71, is unclear.
References
Further reading
- Ganot P, Caizergues-Ferrer M, Kiss T . The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation . Genes & Development . 11 . 7 . 941–56 . April 1997 . 9106664 . 10.1101/gad.11.7.941 . free .
- Bachellerie JP, Cavaillé J, Hüttenhofer A . The expanding snoRNA world . Biochimie . 84 . 8 . 775–90 . August 2002 . 12457565 . 10.1016/S0300-9084(02)01402-5 .
Notes and References
- Kiss T . Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions . Cell . 109 . 2 . 145–8 . April 2002 . 12007400 . 10.1016/S0092-8674(02)00718-3 . 8968788 . free .
