Small nucleolar RNA R32/R81/Z41 explained

Small nucleolar RNA R32/R81/Z41
Symbol:	snoR32_R81
Rfam:	RF00356
Rna Type:	Gene snRNA; snoRNA; CD-box
Tax Domain:	Eukaryota

In molecular biology, Small nucleolar RNA Z41 (homologous to R32 and R81) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.snoRNA Z41 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.^{[1] [2]} Plant snoRNA Z41 was identified in screens of Arabidopsis thaliana.^{[3] [4]}

Notes and References

1. Galardi . S.. Fatica . A.. Bachi . A.. Scaloni . A.. Presutti . C.. Bozzoni . I.. 10.1128/MCB.22.19.6663-6668.2002 . Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro . Molecular and Cellular Biology. 22 . 19 . 6663–6668 . October 2002 . 12215523. 134041.
2. Kiss T . Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions . Cell . 109 . 2 . 145–8 . 2002 . 12007400 . 10.1016/S0092-8674(02)00718-3. 8968788 . free .
3. Barneche F, Gaspin C, Guyot R, Echeverría M . Identification of 66 box C/D snoRNAs in Arabidopsis thaliana: extensive gene duplications generated multiple isoforms predicting new ribosomal RNA 2'-O-methylation sites . J. Mol. Biol. . 311 . 1 . 57–73 . 2001 . 11469857 . 10.1006/jmbi.2001.4851.
4. Qu LH, Meng Q, Zhou H, etal . Identification of 10 novel snoRNA gene clusters from Arabidopsis thaliana . Nucleic Acids Res. . 29 . 7 . 1623–30 . 2001 . 11266566 . 10.1093/nar/29.7.1623 . 31268.