Small nuclear ribonucleoprotein polypeptide A explained

U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the SNRPA gene.^{[1] [2]}

Interactions

Small nuclear ribonucleoprotein polypeptide A has been shown to interact with CDC5L.^[3]

Further reading

• Hoffman DW, Query CC, Golden BL, White SW, Keene JD . RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins . Proceedings of the National Academy of Sciences of the United States of America . 88 . 6 . 2495–9 . March 1991 . 1826055 . 51259 . 10.1073/pnas.88.6.2495 . 1991PNAS...88.2495H . free .
• Nelissen RL, Sillekens PT, Beijer RP, Geurts van Kessel AH, van Venrooij WJ . Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein . Gene . 102 . 2 . 189–96 . June 1991 . 1831431 . 10.1016/0378-1119(91)90077-O .
• Jessen TH, Oubridge C, Teo CH, Pritchard C, Nagai K . Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA . The EMBO Journal . 10 . 11 . 3447–56 . November 1991 . 1833186 . 453073 . 10.1002/j.1460-2075.1991.tb04909.x .
• Nagai K, Oubridge C, Jessen TH, Li J, Evans PR . Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A . Nature . 348 . 6301 . 515–20 . December 1990 . 2147232 . 10.1038/348515a0 . 1990Natur.348..515N . 4336326 .
• Sillekens PT, Habets WJ, Beijer RP, van Venrooij WJ . cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins . The EMBO Journal . 6 . 12 . 3841–8 . December 1987 . 2962859 . 553857 . 10.1002/j.1460-2075.1987.tb02721.x .
• Oubridge C, Ito N, Evans PR, Teo CH, Nagai K . Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin . Nature . 372 . 6505 . 432–8 . December 1994 . 7984237 . 10.1038/372432a0 . 1994Natur.372..432O . 9404488 .
• Howe PW, Nagai K, Neuhaus D, Varani G . NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein . The EMBO Journal . 13 . 16 . 3873–81 . August 1994 . 8070414 . 395300 . 10.1002/j.1460-2075.1994.tb06698.x .
• Allain FH, Gubser CC, Howe PW, Nagai K, Neuhaus D, Varani G . Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation . Nature . 380 . 6575 . 646–50 . April 1996 . 8602269 . 10.1038/380646a0 . 1996Natur.380..646A . 4265453 .
• Avis JM, Allain FH, Howe PW, Varani G, Nagai K, Neuhaus D . Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding . Journal of Molecular Biology . 257 . 2 . 398–411 . March 1996 . 8609632 . 10.1006/jmbi.1996.0171 .
• Lu J, Hall KB . Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy . Biochemistry . 36 . 34 . 10393–405 . August 1997 . 9265619 . 10.1021/bi9709811 .
• Allain FH, Howe PW, Neuhaus D, Varani G . Structural basis of the RNA-binding specificity of human U1A protein . The EMBO Journal . 16 . 18 . 5764–72 . September 1997 . 9312034 . 1170207 . 10.1093/emboj/16.18.5764 .
• Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M . Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex . Nature Genetics . 20 . 1 . 46–50 . September 1998 . 9731529 . 10.1038/1700 . 585778 .
• Ferré-D'Amaré AR, Zhou K, Doudna JA . Crystal structure of a hepatitis delta virus ribozyme . Nature . 395 . 6702 . 567–74 . October 1998 . 9783582 . 10.1038/26912 . 1998Natur.395..567F . 4359811 .
• Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC . The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor . RNA . 4 . 12 . 1493–9 . December 1998 . 9848648 . 1369720 . 10.1017/S1355838298981183 .
• Hetzer M, Mattaj IW . An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins . The Journal of Cell Biology . 148 . 2 . 293–303 . January 2000 . 10648562 . 2174293 . 10.1083/jcb.148.2.293 .
• Klein Gunnewiek JM, Hussein RI, van Aarssen Y, Palacios D, de Jong R, van Venrooij WJ, Gunderson SI . Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation . Molecular and Cellular Biology . 20 . 6 . 2209–17 . March 2000 . 10688667 . 110837 . 10.1128/MCB.20.6.2209-2217.2000 .
• Varani L, Gunderson SI, Mattaj IW, Kay LE, Neuhaus D, Varani G . The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein . Nature Structural Biology . 7 . 4 . 329–35 . April 2000 . 10742179 . 10.1038/74101 . 13432764 .
• Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI . Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry . The EMBO Journal . 19 . 23 . 6569–81 . December 2000 . 11101529 . 305846 . 10.1093/emboj/19.23.6569 .
• Simmons A, Aluvihare V, McMichael A . Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators . Immunity . 14 . 6 . 763–77 . June 2001 . 11420046 . 10.1016/S1074-7613(01)00158-3 . free .

Notes and References

1. Schonk D, van Dijk P, Riegmann P, Trapman J, Holm C, Willcocks TC, Sillekens P, van Venrooij W, Wimmer E, Geurts van Kessel A . Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region . Cytogenetics and Cell Genetics . 54 . 1–2 . 15–9 . January 1991 . 1701111 . 10.1159/000132946 .
2. Web site: Entrez Gene: SNRPA small nuclear ribonucleoprotein polypeptide A.
3. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI . Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry . The EMBO Journal . 19 . 23 . 6569–81 . December 2000 . 11101529 . 305846 . 10.1093/emboj/19.23.6569 .