Small multidrug resistance protein explained

Small multidrug resistance protein (also known as Drug/Metabolite Transporter) is a family of integral membrane proteins that confer drug resistance to a wide range of toxic compounds by removing them for the cells. The efflux is coupled to an influx of protons. An example is Escherichia coli mvrC which prevents the incorporation of methyl viologen into cells^[1] and is involved in ethidium bromide efflux.^[2]

Notes and References

1. Morimyo M, Hongo E, Hama-inaba H, Machida I . Cloning and characterization of the mvrC gene of Escherichia coli K-12 which confers resistance against methyl viologen toxicity . Nucleic Acids Res. . 20 . 12 . 3159–3165 . 1992 . 1320256 . 10.1093/nar/20.12.3159 . 312453.
2. Purewal AS . Nucleotide sequence of the ethidium efflux gene from Escherichia coli . FEMS Microbiol. Lett. . 66 . 2 . 229–231 . 1991 . 1936950 . 10.1111/j.1574-6968.1991.tb04870.x . free .