Small Cajal body specific RNA 14 explained
In molecular biology, Small Cajal body specific RNA 14 (also known as scaRNA14 or U100) is a small nucleolar RNA found in Cajal bodies.
scaRNAs are a specific class of small nucleolar RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1] [2] U100 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure and the conserved H/ACA-box motifs.[3]
U100 is the human orthologue of mouse H/ACA snoRNA MBII-201 which is also included in this family.[4] U100 is predicted to guide the pseudouridylation of U2 snRNA at residue U7.[5]
Notes and References
- Darzacq X, Jády BE, Verheggen C, Kiss AM, Bertrand E, Kiss T . Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs . The EMBO Journal . 21 . 11 . 2746–56 . June 2002 . 12032087 . 126017 . 10.1093/emboj/21.11.2746 .
- Lestrade L, Weber MJ . snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs . Nucleic Acids Research . 34 . Database issue . D158-62 . January 2006 . 16381836 . 1347365 . 10.1093/nar/gkj002 . 10.1.1.105.7552 .
- Vitali P, Royo H, Seitz H, Bachellerie JP, Hüttenhofer A, Cavaillé J . Identification of 13 novel human modification guide RNAs . Nucleic Acids Research . 31 . 22 . 6543–51 . November 2003 . 14602913 . 275545 . 10.1093/nar/gkg849 .
- Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J . RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse . The EMBO Journal . 20 . 11 . 2943–53 . June 2001 . 11387227 . 125495 . 10.1093/emboj/20.11.2943 .
- Schattner P, Barberan-Soler S, Lowe TM . A computational screen for mammalian pseudouridylation guide H/ACA RNAs . RNA . 12 . 1 . 15–25 . January 2006 . 16373490 . 1370881 . 10.1261/rna.2210406 .
