Sloan Creek is a stream in eastern Cape Girardeau County, Missouri, in the United States. It is a tributary to the Mississippi River.
The stream headwaters arise in north Cape Girardeau at 37.3467°N -89.5361°W and it flows southeasterly approximately 2.5 miles through northeast Cape Girardeau to enter the Mississippi due east of Southeast Missouri State College at 37.3147°N -89.5133°W.[1]
The stream was named after the owner of a local mill.[2]