| Slavyanoserbsk uezd | |
| Native Name: | Славяносербскій уѣздъ |
| Native Name Lang: | ru |
| Settlement Type: | Uezd |
| Mapsize: | 225px |
| Subdivision Type: | Country |
| Subdivision Name: | Russian Empire |
| Subdivision Type1: | Governorate |
| Subdivision Name1: | Yekaterinoslav |
| Established Title: | Established |
| Established Date: | 1802 |
| Extinct Title: | Abolished |
| Extinct Date: | 1923 |
| Seat Type: | Capital |
| Seat: |
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| Area Total Km2: | 5089.18 |
| Population As Of: | 1897 |
| Population Total: | 174,753 |
| Population Density Km2: | auto |
The Slavyanoserbsk uezd (; Ukrainian: Слов'яносербський повіт|Slovianoserbs'kyi povit) was one of the subdivisions of the Yekaterinoslav Governorate of the Russian Empire. It was situated in the eastern part of the governorate. Its administrative centre was Slovianoserbsk until 1882 and Luhansk after that.
At the time of the Russian Empire Census of 1897, Slavyanoserbsky Uyezd had a population of 174,753. Of these, 50.5% spoke Ukrainian, 45.4% Russian, 1.5% Yiddish, 0.9% Belarusian, 0.5% German, 0.5% Moldovan or Romanian, 0.3% Polish, 0.1% Romani, 0.1% Tatar, 0.1% Armenian and 0.1% French as their native language.[1]