| Slaheddine Baccouche | |
| Birth Date: | 14 August 1883 |
| Birth Place: | Tunis, French Tunisia |
| Death Place: | Tunis, Tunisia |
| Nationality: | Tunisian |
| Office: | Prime minister of Tunisia |
| Term Start: | 15 May 1943 |
| Term End: | 19 July 1947 |
| Predecessor: | Mohamed Chenik |
| Successor: | Mustapha Kaak |
| Term Start1: | 26 March 1952 |
| Term End1: | 2 March 1953 |
| Monarch1: | Muhammad VIII |
| Predecessor1: | Mohamed Chenik |
| Successor1: | Mohamed Salah Mzali |
| Spouse: | Amina Ben Ayed |
Slaheddine Baccouche (August 14, 1883 - December 24, 1959) was a Tunisian politician. He served as grand vizier of Tunis under Muhammad VIII al-Amin, from 1943 to 1947 and again from 1952 to 1954. His nephew was the writer Hachemi Baccouche.
He is the son of General Mohamed Baccouche, native of Cape Bon, Minister and Counselor beylical; his mother is Mamiya Ben Ayed, from a family of the Caidal aristocracy.
After having held several positions of caid in Sousse and Bizerte, he held the office of Grand Vizier twice during the reign of Lamine Bey from 15 May 1943 to 19 July 1947, and from 26 March 1952 to 2 March 1953.
He is often considered as one of the Tunisian personalities, who opposed the Tunisian national movement, with Mustapha Kaak, Abdelkader Belkhodja or Hédi Raïs.
He is the uncle of the writer Hachemi Baccouche.