Sjögren syndrome antigen B explained

Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene.^[1]

Function

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjögren's syndrome and systemic lupus erythematosus.^{[1] [2]}

Interactions

Sjögren syndrome antigen B has been shown to interact with nucleolin.^[3]

See also

• La domain

Further reading

• Kohsaka H, Yamamoto K, Fujii H, Miura H, Miyasaka N, Nishioka K, Miyamoto T . Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein . The Journal of Clinical Investigation . 85 . 5 . 1566–74 . May 1990 . 1692037 . 296607 . 10.1172/JCI114606 .
• Sturgess AD, Peterson MG, McNeilage LJ, Whittingham S, Coppel RL . Characteristics and epitope mapping of a cloned human autoantigen La . Journal of Immunology . 140 . 9 . 3212–8 . May 1988 . 10.4049/jimmunol.140.9.3212 . 2452201 . 1863804 . free .
• Rauh AJ, Hornig H, Lührmann R . At least three distinct B cell epitopes reside in the C-terminal half of La protein, as determined by a recombinant DNA approach . European Journal of Immunology . 18 . 12 . 2049–57 . December 1988 . 2464497 . 10.1002/eji.1830181227 . 7014818 .
• Chan EK, Sullivan KF, Tan EM . Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding . Nucleic Acids Research . 17 . 6 . 2233–44 . March 1989 . 2468131 . 317593 . 10.1093/nar/17.6.2233 .
• Gottlieb E, Steitz JA . Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III . The EMBO Journal . 8 . 3 . 851–61 . March 1989 . 2470590 . 400884 . 10.1002/j.1460-2075.1989.tb03446.x.
• Chambers JC, Kenan D, Martin BJ, Keene JD . Genomic structure and amino acid sequence domains of the human La autoantigen . The Journal of Biological Chemistry . 263 . 34 . 18043–51 . December 1988 . 10.1016/S0021-9258(19)81321-2 . 3192525 . free .
• Chambers JC, Keene JD . Isolation and analysis of cDNA clones expressing human lupus La antigen . Proceedings of the National Academy of Sciences of the United States of America . 82 . 7 . 2115–9 . April 1985 . 3856888 . 397503 . 10.1073/pnas.82.7.2115 . 1985PNAS...82.2115C . free .
• Svitkin YV, Pause A, Sonenberg N . La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA . Journal of Virology . 68 . 11 . 7001–7 . November 1994 . 7933082 . 237137 . 10.1128/jvi.68.11.7001-7007.1994.
• Tröster H, Metzger TE, Semsei I, Schwemmle M, Winterpacht A, Zabel B, Bachmann M . One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögrens' syndrome . The Journal of Experimental Medicine . 180 . 6 . 2059–67 . December 1994 . 7964483 . 2191769 . 10.1084/jem.180.6.2059 .
• Fan H, Sakulich AL, Goodier JL, Zhang X, Qin J, Maraia RJ . Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes . Cell . 88 . 5 . 707–15 . March 1997 . 9054510 . 10.1016/S0092-8674(00)81913-3 . 2223069 . free .
• McLaren RS, Caruccio N, Ross J . Human La protein: a stabilizer of histone mRNA . Molecular and Cellular Biology . 17 . 6 . 3028–36 . June 1997 . 9154801 . 232155 . 10.1128/mcb.17.6.3028.
• Grölz D, Bachmann M . The nuclear autoantigen La/SS-associated antigen B: one gene, three functional mRNAs . The Biochemical Journal . 323 (Pt 1) . 1 . 151–8 . April 1997 . 9173875 . 1218288 . 10.1042/bj3230151.
• Helsloot J, Sturgess A . T cell reactivity to Sjögren's syndrome related antigen La(SSB) . The Journal of Rheumatology . 24 . 12 . 2340–7 . December 1997 . 9415639 .
• Broekhuis CH, Neubauer G, van der Heijden A, Mann M, Proud CG, van Venrooij WJ, Pruijn GJ . Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution . Biochemistry . 39 . 11 . 3023–33 . March 2000 . 10715123 . 10.1021/bi992308c . 2066/187036 . free .
• Spångberg K, Wiklund L, Schwartz S . HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities . Virology . 274 . 2 . 378–90 . September 2000 . 10964780 . 10.1006/viro.2000.0461 . free .
• Intine RV, Sakulich AL, Koduru SB, Huang Y, Pierstorff E, Goodier JL, Phan L, Maraia RJ . Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366 . Molecular Cell . 6 . 2 . 339–48 . August 2000 . 10983981 . 10.1016/S1097-2765(00)00034-4 . free .
• Nashimoto M, Nashimoto C, Tamura M, Kaspar RL, Ochi K . The inhibitory effect of the autoantigen La on in vitro 3' processing of mammalian precursor tRNAs . Journal of Molecular Biology . 312 . 5 . 975–84 . October 2001 . 11580243 . 10.1006/jmbi.2001.5026 .
• De Nova-Ocampo M, Villegas-Sepúlveda N, del Angel RM . Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA . Virology . 295 . 2 . 337–47 . April 2002 . 12033793 . 10.1006/viro.2002.1407 . free .
• Intine RV, Dundr M, Misteli T, Maraia RJ . Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs . Molecular Cell . 9 . 5 . 1113–23 . May 2002 . 12049746 . 10.1016/S1097-2765(02)00533-6 . free .
• Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ . Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes . Journal of Molecular Biology . 320 . 3 . 475–88 . July 2002 . 12096904 . 10.1016/S0022-2836(02)00518-1 . 2066/121576 . free .

Notes and References

1. Web site: Entrez Gene: SSB Sjögren's syndrome antigen B (autoantigen La).
2. Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ . Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen . Molecular Cell . 21 . 1 . 75–85 . January 2006 . 16387655 . 10.1016/j.molcel.2005.10.027 . 4689297 .
3. Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ . Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes . Journal of Molecular Biology . 320 . 3 . 475–88 . July 2002 . 12096904 . 10.1016/S0022-2836(02)00518-1 . 2066/121576 . free .