| Official Name: | Sixty Six, South Carolina |
| Pushpin Map: | South Carolina#USA |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | South Carolina |
| Subdivision Type2: | County |
| Subdivision Name2: | Orangeburg |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 141 |
| Coordinates: | 33.3058°N -80.8261°W |
| Area Code: | 803, 839 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 1250918[1] |
Sixty Six is an unincorporated community in Orangeburg County, South Carolina, United States. Sixty Six is located along U.S. Route 21, north of Branchville.