| Sixta Pontón de Santander | |
| Office: | First Lady of the New Granada |
| President: | Francisco de Paula Santander |
| Term Label: | In role |
| Term Start: | October 7, 1832 |
| Term End: | April 1, 1837 |
| Predecessor: | Position established |
| Successor: | María Antonia del Castillo |
| Office1: | Second Lady of the Gran Colombia |
| Vicepresident1: | Francisco de Paula Santander |
| Term Label1: | In role |
| Term Start1: | November 3, 1821 |
| Term End1: | September 19, 1827 |
| Predecessor1: | Teresa Rivas Arce |
| Successor1: | Juana Jurado de Caicedo |
| Birth Name: | Sixta Pontón Vargas Piedrahíta |
| Birth Date: | 2 April 1792 |
| Birth Place: | Soacha, Bogotá Province, Spanish Colombia |
| Death Place: | Bogotá, Granadine Confederation |
| Parents: | Mario Pontón Vargas (father) Francisca Piedrahíta (mother) |
Sixta Pontón de Santander (April 2, 1792 –July 28, 1862) was a Colombian philanthropist and politician. She was also the wife of Francisco de Paula Santander.[1] [2] [3] [4]